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Given that research and practice con rm that virtually all children committing extremely serious offences, and many children and young people committing less serious offences, have major emotional, behavioural and social dif culties, it is perhaps surprising that routine requests for psychiatric assessment of child defendants appearing before the courts do not occur very much earlier in the trial process. Studies looking at the characteristics and background of young children committing serious offences have indicated high levels of parental delinquency and psychopathy, childhood abuse and exposure to domestic violence, a higher than expected level of neuro-psychiatric disorders in the offending children, an association with learning disability, academic failure and severe childhood onset conduct disorder (Bailey, 1996; Myers, Burket and Harris, 1995; Myers, Scott, Burgess and Burgess, 1995; Vizard, forthcoming). Research looking at the outcomes for juvenile offenders in adult life con rms that the earlier the onset of offending behaviour, the more likely this behaviour is to persist into adult life (Mof tt, 1993) and to be associated with heavy use of mental health, criminal justice and welfare systems (West and Farrington, 1973; Of ce for National Statistics, 2000). Unlike adolescents in their late teens committing more minor offences such as car theft or burglary, most of whom can be expected to grow out of this behaviour in adult life very young children committing more serious offences are usually much more disturbed and have shown signs of worrying antisocial behaviour from early childhood. Life course persistent conduct disorder (Mof tt, 1993) or antisocial behaviour beginning before age 10 has been associated with later adult disturbance, delinquency and poor parenting (Quinton and Rutter, 1988).
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The focus on patterns of behaviour in popular, anecdotal, crime publications as well as in the limited research literature is in part due to the many complications and unanswered questions within these multivariate issues. Some relate to the versatility of offenders. These raise questions of just what may be regarded as typical or characteristic of an offender. Other dif culties relate to the problem of de ning the subgroup to which an offence should be assigned. Consider, as an illustration, a crime in which a house was burgled and at the same time a re was set, giving rise to the death of an occupant. Would this crime be best thought of as burglary, arson or murder The charge made against the accused is usually for the most serious crime, but psychologically that may not be the most signi cant aspect of the offender s actions. One central research question, then, is to identify the behaviourally important facets of offences; those facets that are of most use in revealing the salient psychological processes inherent in the offence. These carry great potential for answering questions posed by investigators.
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CAUTION: Don t confuse a mortgage banker with a mortgage broker. A mortgage banker puts up money for mortgages; a broker shops for mortgage sources. You may wind up paying extra if you deal with a broker, because the broker is getting paid on top of the cost of the mortgage. On the other hand, a good mortgage broker not only can get you the best deal, but may even help you get the f inancing where you couldn t arrange f inancing on your own.
leptin concentrations are low (Casanueva et al., 1997; Herpertz et al., 2000; Monteleone et al., 2000a) but proportional to BMI and fat mass (Ferron et al., 1997; Grinspoon et al., 1996; Monteleone et al., 2000a), except at extremely low weight (Casanueva et al., 1997; Pauly et al., 2000). The diurnal rhythm of leptin and its relationship with insulin and IGF-1 release are preserved, but the temporal relationship with cortisol is disrupted until weight is restored (Eckert et al., 1998; Herpertz et al., 1998, 2000). Interestingly, there is a dissociation between BMI and leptin levels during weight gain (Hebebrand et al., 1997; Mantzoros et al., 1997) which could contribute to dif culty achieving full weight restoration with rapid refeeding. Similarly, leptin levels are elevated above that expected for BMI in those with the purging subtype of AN (Mehler et al., 1999). Elevation of the CSF : plasma leptin ratio in acute AN (Mantzoros et al., 1997) suggests that central levels may be relatively elevated, perhaps contributing to impairment of appetite. However, normalisation following full recovery from AN (Mantzoros et al., 1997) indicates that altered leptin dynamics are a state-related phenomena. In keeping with this hypothesis, leptin levels are predictive of amenorrhoea in eating-disordered patients (Kopp et al., 1997) and restoration of normal levels is necessary, but not suf cient, for restoration of menses (Audi et al., 1998).
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